Clay has posted some great tutorials about some of the finer details of screen printing that are very helpful. In order to give you the whole picture, I wanted to post this tutorial that goes a little in depth on how to set up a file for a multi-layer screen print. This may seem daunting at first, but once you get working it is very intuitive.
Here is a nice primer on the process. This isn’t an easy piece, but gives you a ton of great info. I would like to possibly touch on this a bit in the beginning of our tutorial as a secondary option to hand painting or perhaps do a follow up.